Compounds of Interest
The following compounds are all inhibitors of JAK3, meaning they would prevent normal functioning of JAK3. They would not be helpful in directly treating someone with SCID, but could conceivably cause SCID in organisms that in turn could be used to study SCID in humans. A summary of related information can be found by clicking on the compound identification number listed next to each compound below. Some of the inhibitors are currently undergoing research to identify potential clinical uses.
Figure 1: jak inhibitor i
WHI-P131 (jak3 inhibitor i)
IUPAC name: 4-[(6,7-dimethoxyquinazolin-4-ly)amino]phenol)
Molecular formula: C16H15N3O3
Molecular weight: 297.3086 [g/mol]
Compound identification number: 3794
WHI-P154 (jak3 inhibitor ii)
IUPAC name: 2-Bromo-4-[6,7-dimthoxyquinazolin-4-ly)amino]phenol
Molecular formula: C16H14BrN3O3
Molecular weight: 376.20466 [g/mol]
Compound identification number: 3795
Figure 2: JAK3 inhibitor ii
Figure 3: jak3 inhibitor iii
WHI-P97 (jak3 inhibitor iii)
IUPAC name: 2,6-dibromo-4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol
Molecular formula: C16H13Br2N3O3
Molecular weight: 455.10072 [g/mol]
Compound identification number: 3796
ZM 39923 hypochloride (jak3 inhibitor iv)
IUPAC name: 3-(N-Benzyl-N-isopropyl)amino-1-(naphthalen-2-ly)propan-1-one hydrochloride
Molecular formula: C23H26ClNO
Molecular weight: 367.91164 [g/mol]
Compound identification number: 176406
Figure 4: jak3 inhibitor iv
Figure 5: jak3 inhibitor v
ZM 449829 (jak3 inhibitor v)
IUPAC name: 1-naphthalen-2-lyprop-2-en-1-one
Molecular forumla: C13H10O
Molecular weight: 182.2179 [g/mol]
Compound identification number: 3779
JAK3 inhibitor vi
IUPAC name: methanesulfonic acid,
(3Z)-5-pyridin-3-yl-3-(1H-pyrrol-2-ylmethylidene)-1H-indol-2-one
Molecular formula: C19H17N3O4S
Molecular weight: 383.42098 [g/mol]
Compound identification number: 16760524
Figure 6: JAK3 inhibitor vi
Figure 7: JAK3 inhibitor (WHI-P258)
WHI-P258 (JAK3 inhibitor)
IUPAC name: 6,7-dimethoxy-N-phenylquinazolin-4-amine hydrochloride
Molecular formula: C16H16ClN3O2
Molecular weight: 317.77014 [g/mol]
Compound identification number: 11359024
